Microdosing TRT The Future of Testosterone Replacement Therapy

Microdosing TRT The Future of Testosterone Replacement Therapy

This area is midway down the first part of the thigh – between your knee and hip. It is not best for men with lower body fat levels but may be worth considering if you are rotating injection sites. Injecting into the belly fat area is recommended as it doesn’t have any structures such https://mydreamsoft.com/experts-warn-of-dangers-and-illegalities/ as blood vessels and nerves close to the skin. It also tends to have a decent layer of adipose (fat) tissue under the skin so that you do not accidentally inject too deep past the subcutaneous layer. The belly area is also easily accessible and viewable to allow easy injections.

• It is important to note that the frequency of your injections will depend on the type of treatment that you are receiving.
• ▪️ If you have long-term treatment with Sustanon you’ll need regular blood tests to monitor your testosterone level, red blood cells, liver function, cholesterol levels and prostate specific antigen (PSA) levels.
• A single dose of Sustanon 250 leads to an increase of total plasma testosterone with peak levels of approximately 70nmol/l (Cmax), which are reached approximately h (tmax) after administration.
• Female-to-male transsexual supportive therapyHysterectomy and bilateral oophorectomy should be considered 18 to 24 months after treatment of testosterone, to reduce risk of endometrial and ovarian cancer.

It is even possible to prescribe medications for an intended purpose when there is no product license, such as Transscrotal Testosterone Cream, but this must be done with extreme caution. ‘Primum non nocere.’ In the private medical sector, practices vary widely, from doctor-led clinics to online providers, generally trending towards increased frequency protocols to help achieve more stable pharmacological levels. Though far from perfect, this generally leads to better outcomes than traditional NHS protocols. A single dose of Sustanon 250 leads to an increase of total plasma testosterone with peak levels of approximately 70nmol/l (Cmax), which are reached approximately h (tmax) after administration. Plasma testosterone levels return to the lower limit of the normal range in males in approximately 21 days.

Tips for Reducing Subcutaneous Testosterone injection irritation

Almost like clockwork, the combination of esters means you can accurately predict blood levels of testosterone. It is necessary for the development of bones and muscles, the growth of hair, and the stimulation of red blood cell production. Sustanon 250 is a testosterone replacement that men over the age of 18 take to treat a variety of health issues caused by a lack of testosterone (male hypogonadism). Regular testosterone levels fall gradually with age and fall quickly following careful expulsion of the balls (for instance in the therapy of testicular disease).

Our team of healthcare experts and GMC registered doctors are licensed to UK GMC standards. It may be necessary for some patients undergoing TRT to take an anti-estrogen such as a Arimidex or Aromasin to curtail estrogenic side effects. Testosterone displays a high (over 97%) non-specific binding to plasma proteins and sex hormone binding globulin in in vitro tests. High doses of androgens may enhance the anticoagulant action of coumarin type agents (see section 4.4). Therefore, close monitoring of prothrombin time and if necessary a dose reduction of the anti-coagulant is required during therapy. Continued surveillance is required to detect endometrial and ovarian cancer in patients on long term treatment who have not proceeded to hysterectomy and bilateral oophorectomy.

Sustanon Side Effects in Testosterone Replacement Therapy

The primary aim of TRT is to achieve stable hormone levels within the body so that homeostasis is maintained. The above data demonstrates that the current recommendations regarding dose and injection frequency do not achieve this. The primary role of hormones is to help maintain homeostasis, a complex process that involves biochemical and physiological mechanisms to help achieve an equilibrium or stability within the body. By that rationale, the aim of TRT and TOT is to restore your levels and achieve stability.

• It also has functions in the skin, muscles, skeleton, kidney, liver, bone marrow and central nervous system.
• The best injection frequency is twice or three times per week if you are injecting a larger amount and prefer to split up your jabs further to reduce injecting large amounts of oil in one go.
• Sustanon 250 contains Arachis oil (peanut oil) (refined) and should not be taken / applied by patients known to be allergic to peanut.
• It’s essential to monitor these side effects and consult a healthcare professional if they become severe.

As a direct testosterone product, Sustanon has the same side effects as other testosterone preparations. Preclinical data with androgens in general reveal no hazard for humans. The use of androgens in different species has been demonstrated to result in virilisation of the external genitals of female foetuses. If symptoms of chronic overdose occur (e.g. polycythaemia, priapism) treatment should be discontinued and after disappearance of the symptoms, be resumed at lower dosage.

You appear to have higher than normal testosterone levels, please contact us for further investigation. When used properly, Sustanon is an option for testosterone replacement therapy. In thrombophilic patients, VTE cases have been reported even under anticoagulation treatment, therefore continuing testosterone treatment after first thrombotic event should be carefully evaluated. In case of treatment continuation, further measures should be taken to minimise the individual VTE risk. Testosterone replacement therapy for male hypogonadism, when testosterone deficiency has been confirmed by clinical features and biochemical tests. Subcutaneous testosterone injections are now the preferred way to inject testosterone cypionate.

Men present with varying degrees of primary (testicular), secondary (brain) and/or tertiary (prolactin) hypogonadism. Again, as a point of reference, the average healthy young male produces approximately 6mg of Testosterone per day, with concentrations as high as 10mg per day 11,12. As we’ve said numerous times before, more is not better, both objectively when assessing biomarkers and subjectively, when describing qualitative well-being. As you can see, despite having healthy trough levels, there was significant variance in his Testosterone level between injections, providing false reassurance of stability. This graph clearly demonstrates the ‘peak and trough’ that is often described by patients on such wide injection intervals. As mentioned before, we should be looking to achieve stable levels.

Therefore, to titrate your optimal dose and frequency, it is sensible to use only one variable. It also makes sense that the action of this variable should be predictable, something that has been demonstrated with testosterone enanthate; oestradiol and DHT levels exhibit saturable increases with increased dose(9). 4 androstene-3b-ol, 17-one (4-Androsterone) – After ingestion, 4-Andro passes into testosterone within a two-stage conversion. The union has a noticeably powerful anabolic effect, resulting in improved muscle mass and strength, while at the same time, the sex drive is noticeably enhanced. 4-Androsterone is an unmethylated prohormone, suggesting it has minimum liver abdominal organs.

On the contrary, we have also experienced positive results with patients using Testosterone Undecanoate, the difference being that we use a more frequent microdose to achieve stability. The reason for the success of Sustanon injections in men is that they contain testosterone esters, which are variations of testosterone, which is naturally occurring in men. This hormone is produced in the testicles, but there are times when the body doesn’t produce enough testosterone for a variety of reasons.